Joseph I Shapiro Selected Research

Adenosine Triphosphatases (ATPase)

7/2022	Tumor-Suppressor Role of the α1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma.
5/2022	Retraction Note: pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet.
5/2022	Retraction Note: The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities.
1/2022	Blockage of the Na-K-ATPase signaling-mediated oxidant amplification loop elongates red blood cell half-life and ameliorates uremic anemia induced by 5/6th PNx in C57BL/6 mice.
1/2022	Gut microbiome and diet in populations with obesity: Role of the Na+/K+-ATPase transporter signaling in severe COVID-19.
11/2021	Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration.
1/2021	The potential role of Na-K-ATPase and its signaling in the development of anemia in chronic kidney disease.
11/2020	The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure.
11/2020	Author Correction: The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities.
8/2020	Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop.

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Joseph I Shapiro Research Topics

Disease

32	Fibrosis (Cirrhosis) 01/2020 - 08/2002
26	Obesity 05/2022 - 01/2013
21	Cardiomyopathies (Cardiomyopathy) 01/2022 - 09/2005
21	Hypertension (High Blood Pressure) 07/2019 - 01/2003
15	Chronic Kidney Failure (Chronic Renal Failure) 01/2019 - 02/2002
13	Heart Failure 12/2021 - 08/2002
12	Renal Insufficiency (Renal Failure) 01/2022 - 05/2003
10	Chronic Renal Insufficiency 01/2021 - 07/2006
10	Cardiomegaly (Heart Hypertrophy) 02/2020 - 01/2003
9	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2019 - 01/2015
9	Renal Artery Obstruction (Renal Artery Stenosis) 01/2019 - 10/2006
8	Insulin Resistance 01/2021 - 03/2012
8	Inflammation (Inflammations) 12/2020 - 01/2013
8	Cardiovascular Diseases (Cardiovascular Disease) 10/2018 - 01/2016
6	Anemia 01/2022 - 02/2002
5	Hyponatremia 01/2021 - 08/2007
4	Atherosclerosis 05/2022 - 09/2011
4	COVID-19 01/2022 - 07/2020
4	Kidney Diseases (Kidney Disease) 12/2021 - 05/2006
4	Proteinuria 01/2020 - 04/2014
4	Myocardial Infarction 01/2018 - 11/2010
4	Pathologic Constriction (Stenosis) 12/2015 - 11/2003
3	Neoplasms (Cancer) 07/2022 - 09/2011
3	Fatty Liver 05/2022 - 01/2015
3	Hypertrophy 01/2020 - 09/2005
3	Stroke (Strokes) 01/2020 - 01/2014
3	Non-alcoholic Fatty Liver Disease 01/2018 - 01/2015
3	Albuminuria 09/2017 - 01/2016
3	Body Weight (Weight, Body) 10/2015 - 05/2003
3	Pre-Eclampsia (Preeclampsia) 02/2012 - 07/2008
2	Hepatocellular Carcinoma (Hepatoma) 07/2022 - 11/2020
2	Infections 01/2022 - 11/2020
2	Hypernatremia 07/2018 - 01/2017
2	Disease Progression 01/2017 - 01/2016
2	Alcoholic Fatty Liver 02/2016 - 01/2015
2	Isolated Systolic Hypertension 01/2016 - 01/2014
2	Ischemia 01/2013 - 11/2010
2	Leukemia 06/2012 - 05/2009
1	Carcinogenesis 07/2022

Drug/Important Bio-Agent (IBA)

41	Adenosine Triphosphatases (ATPase)IBA 07/2022 - 01/2003
19	Oxidants (Oxidizing Agents)IBA 05/2022 - 09/2005
18	Cardiac GlycosidesIBA 01/2019 - 03/2006
15	SodiumIBA 12/2021 - 12/2002
15	marinobufageninIBA 10/2018 - 12/2002
11	pNaKtideIBA 05/2022 - 09/2011
10	Peptides (Polypeptides)IBA 07/2022 - 09/2011
10	SaltsIBA 07/2019 - 12/2010
9	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2016
8	CytokinesIBA 01/2022 - 01/2016
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
8	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 05/2003
8	CreatinineIBA 01/2019 - 11/2003
7	CollagenIBA 01/2020 - 01/2007
6	AntioxidantsIBA 11/2020 - 01/2016
6	AdiponectinIBA 01/2020 - 01/2012
5	NaKtideIBA 11/2021 - 01/2019
5	Sodium-Potassium-Exchanging ATPase (Sodium, Potassium ATPase)IBA 01/2018 - 01/2003
5	Hormones (Hormone)IBA 12/2010 - 07/2008
4	AdipokinesIBA 01/2020 - 01/2016
4	Cystatin CIBA 01/2019 - 10/2011
4	PotassiumIBA 07/2018 - 09/2005
4	MicroRNAs (MicroRNA)IBA 01/2018 - 03/2016
4	Transcription Factors (Transcription Factor)IBA 06/2012 - 05/2009
3	Erythropoietin FDA Link 01/2022 - 02/2002
3	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 01/2017
3	oxidized low density lipoproteinIBA 08/2020 - 01/2016
3	EnzymesIBA 07/2020 - 03/2013
3	LipidsIBA 01/2020 - 01/2015
3	LeptinIBA 01/2019 - 01/2016
3	Antihypertensive Agents (Antihypertensives)IBA 01/2018 - 01/2014
3	Monoclonal AntibodiesIBA 04/2014 - 04/2011
3	Spironolactone (Aldactone)FDA LinkGeneric 01/2013 - 08/2002
3	bufadienolideIBA 06/2012 - 04/2011
2	Retinaldehyde (Retinal)IBA 12/2020 - 04/2016
2	Heme Oxygenase-1IBA 11/2020 - 10/2016
2	RNA (Ribonucleic Acid)IBA 11/2020 - 01/2020
2	Fatty Acids (Saturated Fatty Acids)IBA 12/2019 - 01/2017
2	HDL CholesterolIBA 11/2017 - 01/2016
2	AcidsIBA 08/2017 - 01/2015
2	Blood Glucose (Blood Sugar)IBA 08/2017 - 01/2012
2	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 08/2017 - 03/2013
2	SmokeIBA 01/2017 - 12/2016
2	AlbuminsIBA 11/2016 - 09/2004
2	LigandsIBA 03/2016 - 01/2013
2	Uric Acid (Urate)IBA 01/2016 - 01/2016
2	FructoseIBA 01/2015 - 01/2014
2	Vasopressins (Vasopressin)IBA 11/2014 - 08/2007
2	digoxin antibodies Fab fragments (Fabad)IBA 04/2014 - 06/2012
2	CD40 Ligand (CD40L)IBA 04/2013 - 09/2011
2	Mineralocorticoid Receptor AntagonistsIBA 01/2013 - 08/2002
2	Digoxin (Digitek)FDA LinkGeneric 06/2012 - 07/2008
2	Phenobarbital (Luminal)FDA Link 10/2011 - 07/2010
1	SurvivinIBA 07/2022
1	Apoptosis Regulatory ProteinsIBA 07/2022
1	Annexin A5IBA 01/2022

Therapy/Procedure

17	Therapeutics 07/2022 - 07/2006
16	Nephrectomy 01/2022 - 01/2003
5	Stents 11/2016 - 11/2003
3	Ligation 11/2017 - 09/2004
2	Renal Replacement Therapy (Therapies, Renal Replacement) 11/2016 - 01/2014